Butyric acid and its derivatives are widely used in chemical industry, food, feed, medicine and other fields. Clostridium tyrobutyricum, as a representative strain producing butyric acid by fermentation, has attracted great attention in the industry. The research progress on the production of butyric acid by Clostridium tyrobutyricum fermentation is systematically reviewed, including physiological characteristics, butyric acid production pathway, low-cost substrate development, genetic engineering modification and new reactor application, the research trend of Clostridium tyrobutyricum fermentation fermentation for producing butyric acid is prospected in order to provide some theoretical and methodological reference for the further research.